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Individuals experiencing major effects demonstrated a similar pattern, with a slightly lower proportion in the West (1.1%) than in the Midwest (2.5%), Northeast (2.6%), or South (3.1%) regions (Table 2). Abuse was the most common reason for exposure in the Midwest (40.4%), whereas unintentional-general was the most common in the other regions (Northeast 43.2%, South 41.3%, and West 50.5%). G Includes âunable to follow (judged as a potentially toxic exposure)â Hemp-derived CBD with less than 0.3% THC is federally legal in the US, but check on your local laws regarding carrying hemp-derived CBD. Maximize the benefits of your wellness routine by knowing CBDâs potential side effects, who should avoid it, and key safety precautions to keep in mind while using it. For example, a slightly higher dose in the evening may support sleep, while a smaller morning dose can promote focus without grogginess.â CBD can be sourced from hemp or marijuana, but chemically, CBD is CBD regardless of source. 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