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The study performed by Stanko et al. was a double-blind, placebo-controlled trial which evaluated body composition with a low energy diet and supplementation with pyruvate. Stanko et al. and Kalman et al. both performed several studies evaluating the use of pyruvate in weight loss [19–21]. It is unclear how pyruvate works to promote weight loss, but in rats a lower respiratory exchange ratio has been demonstrated indicating that there was increased utilization of fat and an elevation in resting metabolic rate [21, 29]. Based on the above studies, it appears as though chitosan may be effective to help aid weight loss. This study demonstrated that chitosan may be an effective weight loss supplement . A randomized, double-blind placebo-controlled trial performed by Pittler et al. examined the effects of chitosan on weight loss. Several in vitro studies have shown that chitosan binds dietary fats and bile acids. 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