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Interestingly, the authors proposed that CBD-induced upregulation of oxytocin may exert antipsychotic-like effects and improve social deficits in an animal model of autism-spectrum disorder by modulating endocannabinoid tone , highlighting once again the convergence of multiple potential mechanisms of CBD’s neuropsychiatric effects. More work will be needed to characterize potential sex influences on mechanisms of antidepressant-like effects of CBD in animal models and to see if this finding translates in human clinical trials. Another study found that CBD had sex-dependent effects on cortical neural activity in the rat methylazoxymethanol acetate (MAM) model of aberrant neural signaling in schizophrenia . However, a handful of studies that were excluded from our review have suggested that sex may influence the effects of CBD on neural mechanisms of psychosis in preclinical models. These are designed for targeted relief, particularly for muscle pain, inflammation, and skin conditions. 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