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High-fat KD may require a significant amount of time for adaption in endurance-trained individuals(372). This metabolic shift was observed after a period of KD adhering almost named ‘fat-adapted,’ which has been well-documented in studies since the 1980s(371). The appeal of KD for endurance athletes is likely due to the shift in fuel utilisation, from a carbohydrate-based model to one that utilises fat primarily, of which stores are virtually unlimited compared with carbohydrates (i.e. muscle glycogen)(306). Furthermore, McSwiney et al. investigated the effects on substrate utilisation during incremental exercise and changes in body composition in response to 7 d ad libitum consumption of a KD by athletes in endurance sports(364). There is evidence that those who adhered to a KD comfortably exceeded the time frame shown to produce robust cellular adaptations to ‘retool’ the muscle to increase its capacity for fat oxidation(314). 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At Neurogan, we are dedicated to ensuring the quality and safety of our products by providing third-party lab-tested and full-panel lab results. Moderate strength gummies have 50 mg per gummy. At the 120 min mark, there was no significant difference in blood glucose levels of the P-SG group and the T-SG group from the baseline level (at the 0 min mark). However, the blood glucose levels of the CG and the glucose groups at the 90 min mark were significantly lower than their baseline blood glucose levels (at the 0 min mark). At the 90 min mark, the blood glucose levels of the P-SG and the T-SG groups returned to baseline levels (levels at the 0 min mark). At the 60 min mark, the blood glucose levels of the glucose group and the CG group were lower than the P-SG group and the T-SG groups. The blood glucose levels at the 15 min mark and the 30 min mark were not different between the P-SG and T-SG group. Meanwhile, the peak blood glucose levels in the P-SG and T-SG groups were also lower than that in the CG group. The blood glucose peak of the glucose, CG, and P-SG groups appeared at the 30 min mark after food consumption. Furthermore, lower blood glucose levels were found in the P-SG and T-SG groups compared to the CG at 15 min. The 15 min blood glucose levels in the CG, P-SG and T-SG were significantly lower than that in the glucose group. The OGTT curve was steadier in the P-SG and T-SG groups than in the CG and glucose groups (Figure 1). The glycemic index (GI) and glycemic load (GL) values were then determined to assess the glycemic response to various gummy samples. Sugars in total and partial sugar substitutes gummies, T-SG and P-SG, were substituted by erythritol and maltitol, while sucrose-based gummies were used as comparisons (CG). It was discussed above that GI and GL values are highly dependent on available carbohydrates, so, in this study, we maintain consistent carbohydrate levels across samples (the same theoretical glucose conversion content). This study aimed to explore the effect of sugar alternatives and dosage form of gummies on glycemic response. As far as we know, it is still unclear how maltitol and erythritol affect the structure of gummies and how they affect humans’ blood sugar homeostasis. The chewiness and swallowability of gummies have made them popular among consumers due to the versatility of hydrocolloids in forming specific dosage forms . In general, a higher carbohydrate content causes a greater response to blood glucose levels. It defines legal hemp as a cannabis plant containing no more than 0.3% Delta 9 THC by dry weight. This federal law legalized hemp and all its derivatives on a national level. The intense effects gradually faded back into a state of serene relaxation. 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