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A meta-analysis was published with 11 studies in T2DM patients, in which 10 used GTE and one used brewed green tea at amounts ranging from 400–10,000 mg/day and durations from 8–12 weeks . Clinical studies with beverages fortified with GTE at intakes up to 498.6 mg EGCG/person/day and durations of up to 1 year (median 12 weeks) have been published and do not show evidence of hepatotoxicity . Yates et al. proposed a tolerable upper intake level (UL) of 300 mg/day of purified EGCG, based on human data in healthy adults in a fed state, and an acceptable daily intake (ADI) of 4.6 mg/kg/day, derived from animal toxicity data . EFSA published a review in 2017 and concluded that there is evidence from interventional clinical studies that intake of doses ≥800 mg EGCG/day induced a significant increase in serum transaminases (a marker of liver injury) in treated subjects compared to control . In most populations, a major source of dietary catechins is green tea infusions, which deliver an average of 0.7 mg EGCG/g of brewed green tea (~178 mg/8.5 fl oz) . Of the three with only caffeine, one study in normal weight and one in overweight/obese subjects reported modest weight loss, whereas another in overweight/obese subjects did not. Responses are variable and likely depend on individual sensitivity to caffeine, the existence of co-morbidities, and intake of concomitant medications or supplements . Specific to the U.S., examination of the 2001–2010 NHANES data showed an average daily intake of 186 mg (90th percentile, 436 mg/day) by adults from foods and beverages, including energy drinks . Given the large body of research for some of these ingredients, this review includes the highest quality evidence, focusing primarily on reports from authoritative sources and published systematic reviews and meta-analyses. 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